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Anti-Estrogen Therapy  

What is anti-estrogen therapy?

Anti-estrogen therapy is a general term used to describe hormonal therapy that used to prevent estrogen in the body from helping to make estrogen receptor positive (ER-positive) cancers (such as ER-positive breast cancer) grow.

Methods of anti-estrogen therapy include:

• Drugs that block the synthesis, stimulate the metabolic breakdown, or inhibit the function of estrogen. See our Q&A called "Ovarian Ablation." Examples of classes of drugs that interfere with the synthesis, function, and/or metabolism of estrogen are:

— Aromatase inhibitors
— SERMs
— Anti-estrogen drugs
— Drugs that cause the production of fewer receptors to estrogen on the surface of cells
— GnRH agonists (also called LHRH agonists)

• Radiation treatment of the ovaries with the intention of suppressing the synthesis of estrogen. See our Q&A called "Ovarian Ablation."

• Surgical removal of the ovaries (oophorectomy). See our Q&As called "Ovarian Ablation" and "Oophorectomy."



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