Ovarian ablation is the stopping of the secretion of sex hormones (e.g., estrogen) by the ovaries in order to treat some women with hormone-dependent breast cancer of Stage I and higher. The cessation of the secretion of sex hormones by the ovaries helps to prevent stimulation of the growth of hormone-dependent breast cancer.
Options for ovarian ablation as adjuvant (post-surgical treatment) include:
• Treatment with drugs that work in a manner similar to that of luteinizing hormone-releasing hormone (LHRH), which is also called gonadotropin-releasing hormone (GnRH). Buserelin and goserelin are examples of such drugs. Normally LHRH (GnRH) controls the secretion of the sex hormones, luteinizing hormone and follicle-stimulating hormone by the pituitary gland.
• Radiation treatment of the ovaries
• Surgical removal of the ovaries (by a procedure called oophorectomy)