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Statistics have shown that a woman with an abnormal (mutated) BRCA1 or BRCA2 gene is more likely to develop breast cancer or ovarian cancer than are women lacking these genetic abnormalities. In women lacking mutations in BRCA1 or BRCA2, the lifetime risk of developing breast cancer is 12%.[1]
Women with an abnormal BRCA1 or BRCA2 gene are 3 to 7 times more likely to develop breast cancer than a woman without this genetic alteration. In women with a mutated BRCA1 gene, the lifetime risk of developing breast cancer is 50%. In women with a mutated BRCA2 gene, the lifetime risk of developing breast cancer is 50% - 60%.[1]
Thus, not every woman with an altered BRCA1 or BRCA2 gene will get breast cancer or ovarian cancer. Genetics is just one of a myriad of risks.
Women with abnormal BRCA1 or BRCA2 genes can consider lifestyle factors and medical options to lower their risks of breast cancer and ovarian cancer.
Remember that most cases of breast cancer do not involve an altered BRCA1 or BRCA2 gene. Statistics show that at most, 1 in 10 breast cancers cases involve an inherited altered gene.
REFERENCE:
1. American Cancer Society. Glossary.
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